Glowing gnats Malaria's downfall

[Downfall in infancy].

Glowing tags

Tagging physical objects to get a link from the physical world into some kind of technology has been done for a long time. The most commonly known is probably the barcodes that is used in five billion scans every day. During a project at Xerox Research Centre Europe in Cambridge, we came across the concept of Glow Tags. It is partly an expansion of the more traditional tags by, from a user pers...

Harnessing phytochrome's glowing potential.

Directed evolution of a cyanobacterial phytochrome was undertaken to elucidate the structural basis of its light sensory activity by remodeling the chemical environment of its linear tetrapyrrole prosthetic group. In addition to identifying a small region of the apoprotein critical for maintaining phytochrome's native spectroscopic properties, our studies revealed a tyrosine-to-histidine mutati...

Bacillus Lepræ, Gnats and Bugs

Dear Sir,?You will be glad to learn that Dr. W. J. Goodhue, Medical Superintendent of the Leper Settlement at Molokai, after several years of investigation there, has been able to demonstrate the bacillus lepra? of Hansen in the mosquito and in the bed-bug. I will quote, from Dr. Goodliue'3 official (but as yet private) report to the Hawaian Board of Health : February 10th, 1906. " We have sinc...

Diversifying the Glowing Bioluminescent Toolbox

Advances in chemical design, genetic engineering, and biomedical technologies have contributed to impressive progress in bioluminescence imaging (BLI) of complex biological systems from cells to living mammals. While the technique is prevalent in small animal in vivo molecular imaging applications, most tools have been limited to only a few sets of bioluminescent systems. Now, the Prescher lab ...